Using modern browsers you can rotate a + sign:
.popupClose:before { content:'+';}.popupClose { position:relative; float:right; right:10px; top:0px; padding:2px; cursor:pointer; margin:2px; color:grey; font-size:32pt; transform:rotate(45deg);}
then simply place the following html where you need:
<span class='popupClose'></span>