Using modern browsers you can rotate a + sign:
.popupClose:before {
content:'+';
}
.popupClose {
position:relative;
float:right;
right:10px;
top:0px;
padding:2px;
cursor:pointer;
margin:2px;
color:grey;
font-size:32pt;
transform:rotate(45deg);
}
then simply place the following html where you need:
<span class='popupClose'></span>